1998-2023 Mayo Foundation for Medical Education and Research (MFMER). The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Take your next dose at the regular time. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or to 30 mg 5-ISMN od for one week followed by 60 mg 5-ISMN od for one week. If concomitant therapy cannot be avoided, monitor clinical effects of the . To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Advertising revenue supports our not-for-profit mission. It has a very short duration of action and may not be suitable for some people. However, you should not flush this medication down the toilet. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. What are the side effects of Isosorbide Mononitrate ? To use the sharing features on this page, please enable JavaScript. Please note that only the generic name of each medication is listed below. Accessibility Melanoma is one of the most dangerous forms of skin cancer which develops in the skin cells that produce melanin ( the pigment that gives your skin its color). Isosorbide is a medication used to treat and prevent angina pectoris in patients with coronary heart disease. Overview of herbal medicines and dietary supplements. Click here for an email preview. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Along with its needed effects, a medicine may cause some unwanted effects. Bookshelf It can cause your blood pressure to become dangerously low. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. Natural Medicines. You need to take it every day in order for it to work. Take care, thanks. If it is within 2 hours of the next dose, skip the missed dose. Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. That's why you need to talk with your health care provider before you take herbal supplements if you take prescription medicines. Accessed Sept. 7, 2022. The body tends to develop a tolerance (decreased sensitivity) to ISMN when it is used continuously over 24 hours. Conclusions: Available for Android and iOS devices. Store in a cool, dry place, away from direct heat and light. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. daily and increasing to 40 mg three times daily as necessary, given at 8 AM, 1 PM, and 6 PM), isosorbide mononitrate (starting at 30 mg/day in the morning and increasing to 120 mg/day as necessary), or a transdermal. Changing positions slowly can help lessen dizziness. It might help to keep the room cool and use a fan. See also: aspirin side effects in more detail. This medicine is available only with your doctor's . See also: nitroglycerin side effects in more detail. from the best health experts in the business. Bauer B (expert opinion). It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate. Patient does not provide medical advice, diagnosis or treatment. eCollection 2021. Garlic. Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). This site needs JavaScript to work properly. Your health care provider and pharmacist can help you stay away from unsafe interactions. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. But only about 25% of people who take herbal supplements tell their health care providers. Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. The authors assessed the occurrence of angina pectoris and headache by diary cards while taking into account the number of isosorbide dinitrate sublingual puffs and paracetamole tablets required. https://naturalmedicines.therapeuticresearch.com. coma (loss of consciousness for a period of time). Background: Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not let anyone else take your medication. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. There are 195 drugs known to interact with Data were assessed for carryover and time effects. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). What special precautions should I follow? Some don't work well with prescription medicines. Does Isosorbide Mononitrate interact with other drugs you are taking? All rights reserved. DUMQOL (DUtch Mononitrate Quality of Life) Study Group. If you have an eye condition called glaucoma. It is important that you follow the instructions your doctor gives to you about when to take your doses. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or . Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. Your doctor may tell you to take a pain reliever to treat your headaches. Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. The information on this page is written and peer reviewed by qualified clinicians. Talk to your pharmacist for more details. Do not keep out-of-date or unwanted medicines. Call your doctor for medical advice about side effects. Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. 2017; doi:10.1016/j.jacc.2016.11.078. It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. This drug may make you dizzy. Who should not take Isosorbide Mononitrate? sharing sensitive information, make sure youre on a federal MBBS, MS - General Surgery, mch neuro surgery. US residents can call their local poison control center at 1-800-222-1222. Tachjian A, et al. Check with your doctor immediately if any of the following side effects occur: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, slow, irregular, pounding, or racing heartbeat or pulse, itching, pain, redness, or swelling on the leg, numbness or tingling in the hands, feet, or lips, pain or discomfort in the arms, jaw, back, or neck, pain, tension, and weakness upon walking that subsides during periods of rest, shakiness in the legs, arms, hands, or feet, swelling of the face, fingers, feet, or lower legs, trembling or shaking of the hands or feet, vomiting of blood or material that looks like coffee grounds, Bluish-colored lips, fingernails, or palms. An official website of the United States government. This should pass after a few days. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This is called a medicine interaction. Anti-ischemic and anti-anginal effects of controlled-release and conventional isosorbide-5-mononitrate in stable angina pectoris. Liperoti R, et al. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Natural Medicines. Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure. . Pricing based on most commonly-filled versions: 180 tablets of isosorbide mononitrate 10mg. These side effects may go away during treatment as your body adjusts to the medicine. For haemoglobin formation vit. During pregnancy, this medication should be used only when clearly needed. Do not stop taking it without consulting your doctor. Integrative medicine (complementary and alternative medicine). Alcohol can make the side effects from isosorbide worse. What side effects can this medication cause? A single copy of these materials may be reprinted for noncommercial personal use only. Real test is coronary angiography. you should know that you may experience headaches every day during your treatment with isosorbide. Talk to your provider if you continue to feel dizzy or have a fast heart rate a week after starting isosorbide mononitrate (Monoket). Isosorbide mononitrate (Monoket) is a nitrate vasodilator. Mehta D. Botanical medicines. Limit alcoholic beverages. Almost 70% of older adults use them. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate. The most common side-effect is headache. The narrowing makes it more difficult for blood to flow to your heart muscle. 46 ratings on Drugs.com. Stopping isosorbide mononitrate (Monoket) suddenly can cause you to have a worsening of your chest pain. include protected health information. Accessed Sept. 7, 2022. 19 are major, 174 are moderate, and 2 are minor. The extended-release tablet usually is taken once daily in the morning. Your doctor will prescribe you a short-acting nitrate for you to take if this happens. Some of these interactions can be life-threatening. See the full pregnancy warnings document. No, that's not true all the time. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Take the missed dose as soon as you remember it. Natural Medicines. If this worries you, talk to your doctor or pharmacist about other options. Upgrade to Patient Pro Medical Professional? Generic alternatives may be available. Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. [2] It is taken by mouth. Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . If we combine this information with your protected PMC WebMD does not provide medical advice, diagnosis or treatment. This medication may interfere with certain laboratory tests (including cholesterol levels), possibly causing false test results. Many common herbal supplements interact with common heart medicines. Am J Ther. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Isosorbide mononitrate vs. Amlodipine besylate, Isosorbide mononitrate vs. Bisoprolol fumarate, Isosorbide mononitrate vs. Diltiazem hydrochloride, Isosorbide mononitrate vs. Isosorbide dinitrate, Isosorbide mononitrate vs. Metoprolol succinate, Isosorbide mononitrate vs. Metoprolol tartrate, Isosorbide mononitrate vs. Nitrolingual pumpspray, Isosorbide mononitrate and Aspirin (7,880 reports), Isosorbide mononitrate and Furosemide (6,020 reports), Isosorbide mononitrate and Amlodipine (3,554 reports), Isosorbide mononitrate and Simvastatin (3,508 reports), Isosorbide mononitrate and Omeprazole (3,422 reports), Isosorbide mononitrate and Lisinopril (3,099 reports), Isosorbide mononitrate and Metformin (2,822 reports), Isosorbide mononitrate and Carvedilol (2,589 reports), Isosorbide mononitrate and Clopidogrel (2,524 reports), Isosorbide mononitrate and Acetylsalicylic acid (2,355 reports). Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. Properly discard this product when it is expired or no longer needed. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. This document does not contain all possible drug interactions. Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. View interaction reports for isosorbide mononitrate and the medicines listed below. Aspirin relieves pain and inflammation and helps to thin the blood. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). If you have any questions about this medicine ask your pharmacist. A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. information is beneficial, we may combine your email and website usage information with May also be prescribed off label for Esophageal Spasm. Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. Take this medication by mouth as directed by your doctor, usually twice a day. Swallow the tablet/capsule whole - do not chew or crush it before you swallow. Prescription and OTC Never give it to other people even if their condition appears to be the same as yours. You may report side effects to Health Canada at 1-866-234-2345. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. You may report side effects to the FDA at 1-800-FDA-1088. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. St. Joseph 81 mg Aspirin Enteric Safety-Coated. Accessed Sept. 7, 2022. Saw palmetto. Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. If you notice any other effects, check with your healthcare professional. All rights reserved. The most common side-effect is headache. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Medicines Complete BNF 84th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. Dehydration in Buspar, how severe and when it was recovered? https://naturalmedicines.therapeuticresearch.com. All rights reserved. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient, isosorbide mononitrate consumer information. AskMayoExpert. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). GoodRx works to make its website accessible to all, including those with disabilities. If you have ever had an allergic reaction to a medicine. Many herbal supplements can interact with prescription drugs. National Library of Medicine If your chest pain attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor. Keep all medications away from children and pets. . Drug information provided by: IBM Micromedex. Compare a few possible alternatives below. If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia). Copyright 2023 IBM Watson Health. I would rather take the chance of a heart attack than have no quality of life. If you have an underactive thyroid gland. Accessed Sept. 7, 2022. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Of the total drug interactions, Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness, which could increase the risk of falls. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. The site is secure. Duplication for commercial use must be authorized by ASHP. Do not share this medication with others. Browse all drugs on eHealthMe. HHS Vulnerability Disclosure, Help Isosorbide mononitrate belongs to the group of medicines called nitrates. 72% of reviewers reported a positive effect, while 12% reported a negative effect. I strongly feel that there is coronary ischemia. Does Isosorbide Mononitrate interact with other medications? I took this for 4 days, and my headaches were unbearable. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. It can cause your blood pressure to become dangerously low. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Use of herbal products and potential interactions in patients with cardiovascular diseases. URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. Some people feel dizzy or fall when changing positions, such as going from sitting to standing. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Headache is often a sign that this medication is working. Does isosorbide mononitrate (Monoket) affect your kidneys? Clipboard, Search History, and several other advanced features are temporarily unavailable. Never take more than the prescribed dose. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Along with its needed effects, a medicine may cause some unwanted effects. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Bethesda, MD 20894, Web Policies Don't drink alcohol while taking isosorbide mononitrate (Monoket). Isosorbide may cause other side effects. Ask your pharmacist for a list of the ingredients. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. Read our editorial policy. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. Using this medicine with any of the following medicines is not recommended. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). It works to relax your blood vessels. These relax smooth muscle within the blood vessels, widening them and making it easier for blood and oxygen to reach the heart Calcium antagonists (eg, diltiazem, nifedipine, nimodipine, verapamil). This medicine is available only with your doctor's prescription. Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain ( angina ), heart failure and esophageal spasms. Isosorbide mononitrate (Monoket) is not a medication you take if you think you are having a heart attack. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Isosorbide mononitrate. Select a condition to view a list of medication options. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). Your doctor will probably tell you not to take isosorbide if you are taking one of these medications. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. We asked 34 people what they think about isosorbide mononitrate (Monoket): Get Isosorbide mononitrate (Monoket) for as low as $29.86, 180 tablets of isosorbide mononitrate 10mg.