Elsevier; 2015. p. 3344. Individuals either with dental caries, heavily restored, or cracked teeth, or with orthodontic or prosthetic appliances, or with localised or generalised gingivitis or pulpitis and heavy calculus or using any desensitising toothpaste or mouth wash or any other desensitising products up to six weeks before the study were excluded from this trial. 2017;2017:2. Written informed consent was obtained with a signed agreement plan to visit for six weeks at interim efficacy intervals of day three, week two, week four, and week six. For more great Dental Care products like toothpaste and mouthwash, continue browsing online and buy in-store at B&M. Colgate Sensitive Instant Relief Toothpaste 75ml Product code: 326795 2.49 Subject to availability - visit your nearest store 2019;88:103170. OTC dentifrices with Pro-argin and strontium acetate are effective for immediate pain relief from DH, and FCPS could be the best possible treatment option for long term management of DH. Last updated on May 11, 2021. https://clinicaltrials.gov/ct2/show/NCT04249336. Width 17 Height 5 Depth 3.8 Show More Payment & Refunds Venkataramana S, Jeyaraman SK, Kothimbakkam SSK, Chellathurai BNK. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. Pro-Argin Technology works through a natural process of dentin tubule occlusion that attracts arginine and calcium carbonate to the dentin surface to form a protective seal that provides instant relief.2 2013;41(2):18794. . Thank you for your feedback. A meta-analysis by Yang et al. Ingredients *Calcium carbonate *Water Pak Oral Dent J. A toothbrushing demonstration model from Nissin Company specification [PE-ORT002] was used to explain to the study participants about applying OTC dentifrices for one minute with the participant's finger. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. Network meta-analysis on the effect of desensitizing toothpastes on dentine hypersensitivity. 2020;99(5):51422. ID: NCT04249336 (https://clinicaltrials.gov/ct2/show/NCT04249336), Date of Registration: January 30, 2020 (Retrospectively registered). 2017;9(4):e503. Colgate SENSITIVE INSTANT Relief tannkrem med Pro-Argin teknologi gir umiddelbar* og langvarig smertelindring av ising i tennene. Blocks the pain of sensitive teeth. 1Intervention for Group A denotes BioMin F. 2Intervention for Group B denotes Colgate Sensitive Pro relief. Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. Treatments provided to the patients were OTC dentifrices marketed with the claim of immediate pain relief in DH. J Clin Periodontol 42 (2015), 17, 4. With the exclusive Pro-Argin formula, it provides instant* and lasting** relief by plugging the channels to block tooth sensitivity. 2. 2020;12(2):87. 2015;28(1):404. Oral dentifrices have been marketed for pain relief within a minute for DH. Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. We found more change in pain scores of VAS used for mechanical stimuli with Pro-argin than FCPS as shown in Table 5 that could be relatable with a randomised controlled trial of FCPS and arginine based desensitizers reporting better treatment response of arginine than FCPS in the cold stimulated DH after two weeks to one month, subsequently [40]. was used for statistical analysis. Mockdeci H, Polonini H, Martins I, Granato A-P, Raposo N. Evaluation of ex vivo effectiveness of commercial desensitizing dentifrices. Tel: +381 (0)21 452-910, +381 (0)21 420-758. J Clin Periodontol. Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Lai et al. Naturally, the researchers wondered whether it could help shield a person from acquiring the virus. There was no statistically significant treatment difference between the two (p=0.499). However, we can conclude that both Pro-argin and strontium acetate-based dentifrices disrupt the pathophysiology of DH and are effective for immediate pain relief even one minute after application on sensitive teeth. It also strengthens tooth enamel by helping rebuild weak spots. A randomised controlled, triple-blinded, phase-3 clinical trial was conducted at the Department of Periodontology at Dr Ishrat-ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS) in Dow University of Health Sciences (DUHS), Karachi, Pakistan from September 2019 to December 2020. 2020;99(5):51422. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. Colgate Sensitive Instant Relief Multiprotection Toothpaste gives you clinically proven lasting relief from sensitivity for 8 weeks when you use it twice a day. Effectiveness of dentifrices with new formulations for the treatment of dentin hypersensitivitya meta-analysis. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Post-application changes on SCASS were observed after one minute, three days, two, four, and six weeks, subsequently. Pro-Argin technology helps to seal and repair . 2016;8:114. Dentin hypersensitivity is characterized by a short, sharp pain arising from open dentin tubules in exposed dentin in response to external stimuli, which cannot be attributed to any other defect or disease. 2008;29(8):1S-35S. J Dent Probl Solut. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . Poster #0742, March 2018 AADR. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. Colgate Sensitive PRO-Relief provides you relief from sudden shocks of pain and long-term sensitivity with regular use. Dent Health Curr Res. The formula consists of Arginine, an amino acid naturally found in saliva and also calcium from calcium carbonate. Colgate SENSITIVE INSTANT Relief Repair & Prevent toothpaste provides instant* and long-lasting sensitivity relief and lasting gum protection: PRO-ARGIN Technology repairs sensitive areas of the teeth for instant and long-lasting pain relief1,2, Zinc helps to strengthen gums and to prevent recession a key cause of sensitivity3. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste with Pro-Argin Technology and Zinc. It improves gum health and helps reduce factors that contribute to gum recession, a leading cause of tooth sensitivity. Layer T, Hughes N. Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity. Yang ZY, Wang F, Lu K, Li YH, Zhou Z. Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis. Our study included an Asian population, and most of the published literature was associated with the Caucasian population. Sriranganathan D, Chen X, Hing KA, Kanwal N, Hill RG. Colgate Sensitive Pro Relief can be applied directly to the affected area for almost instant relief. and Ayad et al. Therefore, this trial was planned to investigate the clinical efficacy of Pro-argin and strontium acetate for immediate pain relief in DH after one minute of topical application to fill the research gap associated with limited published evidence and risk of bias in selection, performance, attrition, and reporting as predicted by Pessoa et al. J Non Cryst Solids. 0. Privacy There was a significant (p<0.001) reduction of 45.7% with Pro-argin, 37.6% with 8% strontium acetate, 18.1% with FCPS, and 15.2% with NaF-based dentifrices relative to baseline on SCASS after one-minute application on sensitive teeth. HOW LONG CAN A PATIENT USE Colgate SENSITIVE INSTANT Relief Repair & Prevent? Mason S, Hughes N, Sufi F, Bannon L, Maggio B, North M, et al. DH most commonly involves the facial surfaces of maxillary and mandibular permanent teeth. Gillam D, Hill R, Samueli A. Bioactive glasses in the management of dentine hypersensitivity: a review. Yes, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste should be used for twice daily toothbrushing to provide ongoing relief from the pain of sensitive teeth. 4 Hines D et al. In each study, a single fingertip application of Colgate Sensitive Pro Relief was found to provide significant immediate relief relative to the comparative toothpaste, a result that was maintained over the subsequent three days with twice-daily brushing with the same toothpaste. J Clin Exp Dent. Anvnd tv gnger dagligen. Cite this article. YYYY Colgate-Palmolive Company. 4.2 5 0 221 221 Colgate Sensitive Pro-Relief Enamel Rebuild toothpaste helps instantly repair sensitive teeth and provides lasting protection against hypersensitivity. Gentle whitening formula. J Dent. The secondary objective of the study was to compare the clinical efficacy of Pro-argin, strontium acetate, and FCPS for immediate and sustained treatment response in DH that was measured on SCASS as a primary outcome measure and VAS as secondary outcome measure at efficacy intervals of one minute, day-three, week two, four and six. Follow the directions for use. 2009; 20 (Spec Iss): 1722. J Clin Periodontol. Hines D: Poster #0742 March 2018 AADR. WHAT IS THE FLUORIDE CONTENT OF Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE? The study's primary objective was to investigate pain relief in one minute after topical application of Pro-argin and strontium acetate on sensitive teeth in DH. There was statistically no significant difference in the baseline characteristics of gender, age, baseline mean scores of clinical parameters of SCASS, and VAS used for mechanical and water jet stimuli between the four treatment groups (p>0.05). J Clin Dent. In vitro analysis suggested that FCPS-based dentifrice enabled the slow and sustained release of fluoride contents, resulting in more stable fluorapatite crystals in saliva [14, 15]. With regular use, it reduces teeth sensitivity and helps to strengthen gums and prevent gum recession. Participants were recalled at interim efficacy intervals of three days, two weeks, four weeks, and six weeks for assessment of sustained relief. For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. Moreover, there was no significant difference between dentifrices containing FCPS, Pro-argin, and 8% strontium acetate (p>0.05) on completion of trial after six weeks. Follow the directions for use. Based on the synthesis of study results, we can conclude that Pro-argin in Colgate Sensitive Pro-relief and 8% strontium acetate in Sensodyne Rapid Action both are effective for pain relief in one minute after application in DH with better immediate treatment response of Pro-argin than strontium acetate. Colgate Sensitive Pro-Relief (Toothpaste): 1.9 out of 5 stars from 91 genuine reviews on Australia's largest opinion site ProductReview.com.au. 2017;30(4):2216. Google Scholar. However, there was no significant treatment difference between dentifrices containing Pro-argin and strontium acetate (p>0.05) at each efficacy interval. Dentinal tubules occluded by bioactive glass-containing toothpaste exhibit high resistance toward acidic soft drink challenge. who examined FCPS and Pro-argin formulations in 2018. 2017;2017:2. Colgate Sensitive Pro-Relief toothpastes have been formulated to provide instant and lasting relief from the pain associated with sensitive teeth. Hu et al. Pro-Argin technology is occlusive. However, strontium acetate can potentially obliterate dentinal tubules by replacing the calcium ions of hydroxyapatite crystal lattice structure withstrontium ions along with its nerve depolarisation treat DH [7]. Colgate Sensitive Pro Relief Whitening Toothpaste 75ml tube (Pack of 4) Instant and Lasting Relief Clinically Proven with Active Ingredients We have a surprise for you Find out all personalised promo codes that you are eligible for. Colgate-Palmolive Company 2018. Most sensitive toothpastes primarily numb the discomfort, whereas Colgate Sensitive Pro-Relief works to relieve sensitivity by plugging the channels that lead to sensitive tooth nerves. Desensitizing toothpastes depolarize the nerves to reduce pain signals to the brain, while occlusives block the dentin tubules to prevent painful stimuli affecting dentinal fluids. To alleviate their tooth sensitivity problem, by using Colgate Sensitive Pro-Relief will give them lasting relief and they can drink ice water freely. Toothpaste doesn't only clean your teeth; we have products to help with a variety of tooth issues like sensitivity and more. Dentine hypersensitivity. The treatment difference between Pro-argin and 8% strontium acetate was not statistically significant with a p>0.05 for immediate and sustained pain relief in DH and statistically significant relative to control on all clinical parameters of the SCASS and VAS. CONSORT flow chart. Published literature [16, 31, 43] has determined that all previous trials on treating DH were conducted on smaller samples, which might have prevented the results from being extrapolated on the general population. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth (with continued use twice a day). Prevalence of dentin hypersensitivity: systematic review and meta-analysis. The main etiological factors are abrasion and erosion that may or may not be associated with gingival recession in DH. WAF has contributed to revising the manuscript critically and contributed to statistical analyses. The sensitive toothpaste remineralises tooth enamel for more resistance against acid attacks. Colgate Sensitive Instant Relief Toothpaste starts blocking sensitivity pain instantly*. The current study outcomes showed significant decrease in pain scores of air-blasts and water jet stimulated DH with FCPS based dentifrices compared to Pro-argin and 8% strontium acetate after two, four, and six weeks subsequently, as depicted in Tables 4 and 5. Colgate uses need to categorize. 2018;9(3):3306. Post-hoc analysis revealed a significant reduction in DH scores in treatment arms compared to control on completing the six-week trial (p<0.05). Matranga D, Matera F, Pizzo G. Evaluating the statistical methodology of randomized trials on dentin hypersensitivity management. Cookies policy. In addition, patients were educated regarding the cause of the disease for prevention and awareness of oral hygiene measures, brushing techniques, and dietary influences in DH. Colgate Sensitive Instant Relief Whitening Toothpaste 75 ml Pack of 5, Blocks Pain Instantly, Prevents Sensitivity, Gently Removes Stains (5 x 75 ml) 1,230 5 offers from 12.50 Colgate Sensitive Pro Relief Enamel Repair Toothpaste 75ml - 4 packs 94 22 offers from 14.14 Colgate Sensitive Instant Relief Enamel Repair Toothpaste 75 ml 190 Use regularly to enjoy long-lasting relief from sensitivity*. Colgate Sensitive Pro Relief Teeth Whitening Sensitivity Toothpaste, 75ml 4.9 out of 5 stars 12 7 offers from SAR 33.95 Colgate Sensitive Pro Relief Base Instant Sensitivity Relief Toothpaste, 75ml 4.3 out of 5 stars 20 5 offers from SAR 31.25 Colgate Total 12 hour Protection Pro - Gum Health Toothpaste 75ml Colgate Sensitive Pro Relief was compared to a leading brand of desensitizing toothpaste containing stannous fluoride in a laboratory study, with confocal laser scanning microscopy and a novel imaging program used to qualify dentinal tubule occlusion. J Clin Dent. 1). 2016;36(3):4403. The statistician was also kept blinded. In this way, variability in individuals' pain response was tried to be controlled and will be discussed in part 2 of this manuscript. These then interact to form a complex with positive charge. They reported more clinical efficacy with BioMin than Pro-argin reduction in air-blast stimulated DH on VAS after one month [39]. ClinicalTrial.gov: National Library of Medicine (US). Oral dentifrices have been marketed extensively for pain relief in one minute after topical application on sensitive teeth, with the claims of several dentists recommending the formulations containing Pro-argin and 8% strontium acetate. Lasting protection with regular use. Read our disclaimer for details. Colgate Sensitive Instant* Relief Enamel Repair Toothpaste gives you clinically proven lasting relief** from sensitivity for 8 weeks when you use it twice a day. 2017;71:18. It contains clinically proven Pro-Argin technology which provides instant and lasting sensitivity relief. Hines D, Rinaudi L, Xu S, Lavender S, Pilch S: The Use of Confocal Laser Scanning Microscopy and a Novel Imaging Program for Quantifying Dentine Tubule Occlusion.