those that have reached the blastocyst stage - makes an ongoing pregnancy more likely. All blastocysts must hatch in order to implant (similar to a chicken that has to hatch out of its egg when born). Rienzi L, Gracia C, Maggiulli R, LaBarbera AR, Kaser DJ, Ubaldi FM, Vanderpoel S, Racowsky C. Hum Reprod Update. (847) 531-4790. 2005-2023 Healthline Media a Red Ventures Company. Poor quality embryos included embryo grades 6CA, 6AC, 6CB, 6BC, 6CC, 5CA, 5AC, 5CB, 5BC, 5CC, 4CA, 4AC, 4CB, 4BC, 4CC, 3CA, 3AC, 3CB, 3BC and 3CC, which had a live. Like the ICM, trophectoderm quality depends on the number of cells and how cohesive and packed together they are. There are a lot of reasons: I cover all of these points in my post Why do embryos in IVF fail to implant or miscarry? The usual way is by using the Gardner system, as I explained above. 2019 Oct 2;34(10):1948-1964. doi: 10.1093/humrep/dez163. The ICM actually becomes the fetus, while the trophectoderm becomes the placenta! In the reproductive system, embryos and eggs naturally have a protective protein shell called the zona pellucida (ZP). 0000009151 00000 n Some clinics will also only call the embryo a 5 if there are many cells hatching out, while others have a lower threshold and might only require a single cell to be hatching out. Archived discussions are usually a bit older and not as active as other community content. The site is secure. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. 1994 . Here are some pictures of day 5 embryos (blastocysts) and their grades. At 30 years old approximately 30% of eggs (and embryos) are chromosomally abnormal By age 37 the average rate of chromosomal abnormality is 45% 75% of embryos are abnormal by age 42, and 90% by age 44 Some studies have shown that there is a higher percentage of chromosomal abnormalities in day 3 embryos than in day 5 embryos. Inactive. Of these, 436 cycles entailed transfer of a NFH blastocyst (n = 123 fresh transfer, n = 313 frozen/thawed embryo transfer (FET)) and 372 cycles entailed transfer of an FH blastocyst (n = 132 fresh, 240 FET). The one thing we are sure about is that the grades given to an embryo gets dont necessarily seal its future. 2017 found that while 10 experienced embryologist were able to consistently choose the best embryo for transfer, they werent consistent with grading. Good quality embryos had 7-8 cells and <10% fragmentation, while fair/poor had <5 cells and 30-50% fragmentation. The rate of triplets with blast transfers at our IVF center has been about 2% of pregnancies. Ferreux L, Bourdon M, Sallem A, Santulli P, Barraud-Lange V, Le Foll N, Maignien C, Chapron C, de Ziegler D, Wolf JP, Pocate-Cheriet K. Hum Reprod. (2016). All rights reserved. 2 = small cavity filling a third of the embryo. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. @sprbaby2013, I looked, didn't see anything specific for hatching blastocysts just unspecified five day transfers. Racowsky C, et al. Terms are highlighted every 3rd time to avoid repetition. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Bookshelf (2018) found that hatched euploid embryos had lower clinical pregnancy rates compared to unhatched euploids (53.45% vs 43.87%). My hCG was 17,810 today. Secondary outcomes were similar between groups: BPR (74.1% versus 72.9%, respectively, OR 1.1; 95% CI: 0.7-1.6), LBR (55.0% versus 50.0%, OR 0.8; 95% CI: 0.6-1.1) and EPL rate (18.9% versus 22.9%, respectively, OR 0.8; 95% CI: 0.5-1.2). This embryo generated a new hESC line, HS475. Other things that fertility specialists will take into account when examining a 3-day embryo are: Day 3 embryos are graded according to two criteria: Some fertility clinics prefer to transfer embryos once they reach day 5. Surrounding the blastocyst is the zona pellucida, or zona for short, which is like a shell that was originally present in the egg and carried on. Heres an example of a cleavage stage embryo with around 8 cells: Usually around day 4 the cells undergo compaction to form a morula. I equate this to a kind of cocoon where the cells of the embryo start to change, or differentiate, into the cells of the blastocyst, which is a very different structure compared to the cleavage stage embryo. For example, at first glance, getting a C grade on the quality of ICM may seem like bad news. I havent found too much research on it but Kirienko et al. Theres quite a bit of data Ive compiled on these embryos, and you can check it out on my Grade C (poor quality) embryo success rates post, but heres one of them: Blastocyst grading is done primarily using the Gardner system. Oliva M, Briton-Jones C, Gounko D, Lee JA, Copperman AB, Sekhon L. J Assist Reprod Genet. I really hope it works out this time for you. (2022)compared the outcomes of day 5, 6 and 7 blastocysts that were tested for PGT-A (and were euploid). 0000009313 00000 n Its used as a way to rank embryos for transfer, with the better quality embryos having a higher chance of implanting compared to the lower quality embryos. Please enable it to take advantage of the complete set of features! We thought it was better to let those slower embryos develop and expand more in the culture dish before choosing the best 1 or 2 for transfer. Need help understanding your day 3 embryo grade and picture? Copyright 2021. 2011). Sagi-Dain L. Sagi S. Patients selected for blastocyst transfer tend to be younger and have more embryos that look better under the microscope (better embryo quality). 3 = partial expansion of the cavity filling at least 50% of the embryo. Short Protocol. In cases where preimplantation genetic screening (PGS) or now known as preimplantation genetic testing for aneuploidy (PGT-A), assisted hatching is one of the techniques used by laboratories prior to biopsy to optimize the biopsy procedure. We avoid using tertiary references. These features depend on what stage of development the embryo is in. We discuss their journey and provide expert advice on finding support. The first step of the IVF process is stimulating your ovaries to produce multiple mature eggs, using fertility medication. However, no studies have reported the possible effects of transferring cryopreserved blastocysts developed from poor-quality cleavage stage embryos on pregnancy and perinatal outcomes. BFP - No heartbeat and growth 3+wks behind at 9 wks . Embryos are normally thawed in the morning but your transfer might not be until later in the day, which gives it time to continue developing. Of the 464 Ex/HgBl transfers, 68.53% resulted in a positive -HCG test, while 122 of CHBl transfers (57.55%) resulted in a positive -HCG test (p=0.005). We explore the impact of infertility on your mental health and ways to feel better. My clinic just puts a blanket name of pgd over all the testing. Your embryo is super strong and continued to do its thing after the thaw. Wijnland Fertility grades embryos according to three parameters. 0 Design: Retrospective analysis in a private reproductive technology program. Epub 2019 Sep 2. The blastocyst is designated a numerical value between 1 and 6. government site. The amount of fragmentation (given as a percentage), How similar in size each cell is (symmetry), Fair/poor quality embryos: 11% live birth rate. This has led to improvement in the outcome of IVF nationwide. If you want to learn more about embryo compaction and how success rates might be impacted, check my post What is Embryo Compaction? These two cell types are important when it comes to blastocyst embryo grading. Disclaimer: Any studies presented here may be contradicted by other studies. Find out whether genetics play a. They want to see that each cell has a nucleus and that the cells are of equal size. My RE automatically does assisted hatching prior to the implantation as some women have issues with the hatching process, plus it's one step closer to implantation which my RE said was a great thing. 0000007041 00000 n Need help understanding your day 5 (blastocyst) embryo grade and picture? Embryo grading is used during IVF to rank embryos for transfer after evaluating different parts of the embryo. Conclusions: In frozen embryo transfers with euploid, good morphologic quality embryos, completely hatched blastocyts at the time of transfer resulted in a significantly lower pregnancy success compared to the transfer of expanded or hatching blastocysts. You can see this below: If you wanted to read more about this last study you can check my post Transfer of day 7 embryos a viable option. 0000004838 00000 n Hatching blastocyst with average number of cells in ICM, even trophectoderm layer. First letter (A to C)- Inner cell mass (ICM) quality. Blastocystes were transferred to almost 90% of group 2 patients. Some may prioritize the ICM quality over the trophectoderm quality, while others may look more at the expansion. These results suggest that reduced success rates associated with fresh transfers of later developing blastocysts may be the result of asynchrony with endometrial receptivity instead of poorer embryo quality. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Because the cells can slip out easily, the zona doesnt thin out as the embryo grows. Can you explain assisted hatching? During ICSI, a single sperm is injected into an egg to fertilize. There are a few techniques that can be used to perform AH and the most popular technique is by the aid of a laser. Theres a reason embryos are graded. Honestly I'm not finding a lot of success with FET in general. The month leading up to an IVF cycle is critical for preparing. First round was bfn and now waiting to see how this second round goes - beta is Friday!! My first son was a hatching blast (both sons are pgd singleton) and my last was getting ready to hatch (plumping up on one side). Finally, the conditions and protocols used in the IVF laboratory can also impact the euploid blastocyst transfer success rates. 0000034981 00000 n For blastocyst stage embryos (day 5, 6 or 7), embryo grading is based on the embryos size (expansion) and the quality of the inner cell mass (ICM) and trophectoderm. Instead, the embryo just starts to grow out of the hole and the zona stays thick. Click here to view the SART Snapshot Report for AFCC. Fully hatched blastocysts (n73) showed a signicantly lower PR (42%) when compared to blastocysts with a blastocoel of more than . Furthermore, whats an A to one embryologist may be a B to another (even from the same clinic!). Embryos with 7 or more cells on day 3 tend to have the best live birth rates based on this study, while embryos with 6 or fewer cells are predicted to do a bit worse. Having 4 cells was ideal and resulted in ~30% live birth rate. Does anyone have experience with a 5 day blast being fully hatched before it is frozen? Interestingly, like most things in IVF, the answer is not clear! The Prelude Connect App is now available for AFCC patients! You can see that the success rates for day 7 embryos are acceptable from the data above. 8600 Rockville Pike Note that once you confirm, this action cannot be undone. Fresh and FET cycles and associated clinical outcomes were considered separately. Generally early blasts have a lower success rate compared to expanded blasts, which have a lower success rate compared to hatching blasts. NickieB. (773) 794-1818, 820 E Terra Cotta Ave, Crystal Lake, IL 60014 Your embryo (now called a blastocyst) is hard at work dividing and building up the number of cells. These develop into the fetus. This is usually done before freezing to remove the water from inside the embryo. There are different stages as the embryo develops, including the cleavage stage, morula stage and the blastocyst stage. Embryo selection for single embryo transfer is much easier due to the better embryo developing more strongly from day 3 to day 5. Bouillon et al. Lets dive in. 0000058518 00000 n The number of cells in a cleavage stage embryo has to do with how fast it divides. What is known already: After adjusting for age, BMI, endometrial thickness at the LH surge and oocytes retrieved in a logistic regression (LR) model, the hatching status remained not associated with IR (P > 0.05). Epub 2014 Feb 26. (2022), which looks at the % of mature eggs that go on to form blastocysts: You can read the full study in my post Age-specific blastocyst conversion rates and other IVF outcomes in good prognosis women. Remember the cytoplasmic pitting we mentioned? So, as an example, you may have a day 5 embryo thats graded as 5AA. Limitations, reasons for caution: In this time, the embryo cant yet use its genome to make the proteins it needs to divide and grow, so it uses stored factors that were left behind in the egg to develop. If you want to check out the full summary you can check my post Is a fully hatched embryo more fragile than an unhatched embryo? Trophectoderm biopsies were performed on Day 5 (d5) or 6 (d6) for embryos meeting morphology eligibility criteria (set at 3BC). Generally, embryos with a high degree of fragmentation also show signs of irregular symmetry, because as fragments are lost the cell itself gets smaller. I had a fully hatched blast transferred yesterday. Du et al. This is a question sometimes asked when people have a fully hatched (expansion 6) embryo. In vitro fertilization (IVF) is a type of assistive reproductive technology (ART) that involves retrieving eggs from a womans ovaries, fertilizing. startxref In this retrospective study, the clinical value of transferring blastocysts derived from day . Again, the trophectoderm grade can be variable depending on the embryologist. Can't wait to hear good news from you on Friday. During the thawing process the embryo fully hatched from its shell prior to transfer. DOI: Increased success and safety in assisted reproductive technology by using elective single embryo transfer. All cells the same size resulted in ~30% live. The embryo grows to form a blastocyst - a clump of cells (inner cell mass) inside a hollow ball of trophectoderm cells. Hatching may not always take place but it is a necessary step towards implantation and pregnancy. There is no guarantee of an improved live birth rate. Last cycle we had a 4AB and 4AB/C put back without success so hoping for better luck with . That's great! Study question: These are cleavage stage embryos because the cells cleave, or split, to form a new cell. 0000058651 00000 n 0000010327 00000 n So while a 3CC is indicated here as having a 34.1% live birth rate, thats part of a larger group of poor quality embryos which may have had more 5ACs or 4BCs for example that may have tilted the success rates. (2020) found that good prognosis women who transferred up to 3 euploid embryos (one at a time, for a total of three transfers) had a cumulative live birth rates of 92.6% by the third transfer. Giulia et al. For women over 42, however, it's less than 10%. (2016). (2023) found that poor quality day 5 embryos had comparable outcomes to day 6 good quality embryos. Predicting live birth rates, multiples based on 223,377 transfers, Grade C (poor quality) embryo success rates, Increased risk factors with blastocyst transfer vs cleavage stage, Predicting how many day 3 embryos make it to blastocyst, Transfer of day 7 embryos a viable option, Age-specific blastocyst conversion rates and other IVF outcomes in good prognosis women, Fertilization and the pronuclear stage (day 0), Cleavage stage embryo grading (day 2 or day 3 embryo grading). I found one from NYU that says 1dp5dt the embryo begins hatching out of its shell and 2dp5dt It continues to hatch and begins to attach to the uterine wall. LBR was defined as the delivery of a live infant after 24 weeks of gestation. 0000004090 00000 n A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. T32 GM007280/GM/NIGMS NIH HHS/United States, NCI CPTC Antibody Characterization Program. Disclaimer: These pages are meant purely for informational purposes. Embryos can be artificially compacted, or collapsed, by using a laser. After adjusting for age, BMI, endometrial thickness at the LH surge and oocytes retrieved in an LR model, the hatching status was not shown to be associated with implantation (P > 0.05). I have two baby boys from 4 transfers thus far (2y7m and 8m). This doesnt mean that a low quality embryo wont go on to form a pregnancy. 9 between the rate of good-quality blastocysts (per D2 embryo) cultured under 5% O2 (good-quality blastocyst rate = 16%) and under 20% O2 (good . In fact, this scenario (the presumably lower quality embryo resulting in pregnancy and birth) has played out many, many times. Heres a handy quick guide to help you put it all together: As mentioned, some clinics might use D in addition to ABC, while others may use A-F. Others may use grade I in place of A or use a + or - sign where an A+ would be a perfect grade. Let's start by reviewing how blastocysts are graded: NUMBER: The number refers to the degree of expansion of the embryo's cavity and goes from 2-6. These develop into the placenta and other tissues that your body needs for the pregnancy. La Jolla Light. Youre past egg retrieval. Alternatively, frozen eggs can be thawed and fertilized, and the day the eggs are thawed will be day 0. The outer layer of cells, the trophectoderm, undergoes a process called hatching, where it thins out and breaks open, allowing the blastocyst to attach to the uterine . 2005-2023Everyday Health, Inc., a Ziff Davis company. Mine was basically fully hatched at thaw and stuck nicely! Years ago, it was a struggle to keep fresh embryos alive and healthy in the lab for more than 3 days. D is for extremely poor ICMs. 0000004311 00000 n You can think of them as birthday cakes divided into slices. My RE assures me that people do . Do the reproductive outcomes from the transfer of fully hatched (FH) blastocysts differ from those of not fully hatched (NFH) blastocysts? Infertility can affect your mental health. These were kind of house rules, and werent dictated by any studies that I know of. :). Morbeck (2017) did a review of 8 studies that drew conclusions based on whether the ICM, trophectoderm, or expansion were the most predictive for implantation: This is the kind of thing that should be deferred to the clinic. National Library of Medicine Unauthorized use of these marks is strictly prohibited. Wijnland emphasizes that additional treatments like assisted hatching should only be offered to cases that meet the criteria so assisted hatching isnt suitable for every patient going through IVF. Laser-assisted hatching is currently the safest, In cases where preimplantation genetic screening (PGS, preimplantation genetic testing for aneuploidy (, PGT-A), assisted hatching is one of the techniques used by laboratories, Embryos that have undergone hatching prior to biopsy have been. Well get into all the statistics and the studies below, so stay tuned! We work hard to share our most timely and active conversations with you. may be contradicted by other studies. Good Luck!!!! I'm having my FETon the 16th and the nurse told me that they will perform the assisted hatching after the thaw. Miscarriages increased from 9% in the good group to 16% in the fair/poor group. Input your search keywords and press Enter. I recall you are doing ivf to avoid passing genetic condition to offspring - which is same reason I'm here too. Alikani et al. No additional funding was received. Here are 6 books that can support your IVF journey. If youre looking for positive signs after an embryo transfer to indicate that you successfully became pregnant, there are several notable ones. The expansion is the number portion and goes from 1-6, while the quality of the ICM and trophectoderm is indicated by a letter, where A is good, B is fair and C is poor. Check here for the full glossary (please excuse the repeated terms!). Even the best of the best, a PGT-A tested euploid embryo, doesnt always work! D. DearPrudence2015. Hopefully, that one will pass through PGD and PGS. Finally, well go over why embryo grading doesnt tell us everything. Usually its based on the fragmentation: The second number (4 in this case) is the number of cells. Normally embryos should become blastocysts on day 5, but sometimes embryos take longer to develop and may become a blastocyst on day 6 or even day 7. Aneuploid embryos tend to not implant, or fail to have sustained implantation. 0000035350 00000 n I will not grade the embryo, since this is best done by your embryologist who had access to the microscope. So, the rule of thumb is that although things arent clear cut, it does seem that the number of cells in an embryo is the best indicator of whether an embryo will thrive or not. We further evaluated for differences in fetal cardiac activity in different subgroups and found that there was no statistically significant difference in fetal cardiac activity between day 5 versus day 6 Ex/HgBl and CHBl (p=0.38). This post will mostly be with day 3 embryos in mind, but day 2 will be included where I can! Last medically reviewed on June 30, 2020. (2018)looked ateuploidembryos in women <35: So grading appears to give euploids a ranking order for transfer, just like what weve seen with untested embryos. Age is a critical factor as well as the endometrial environment where the embryo implants. Remember the story about the tortoise and the hare. Remember, theyre like water balloons, and sometimes this balloon can pop to release the water. Both were FETs. This means that doctors can now transfer a single blastocyst with a good chance of success. Consult with your doctor before making any treatment changes. For cleavage stage embryos, or day 2 or day 3 embryos, these features are typically: For morulas, these features are typically: For blastocysts, these features are typically: In addition, the number of days it took the embryo to become a specific stage is considered. 2021 Mar 18;36(4):929-940. doi: 10.1093/humrep/deab014. March 4, 2023 11:43 AM PT. Improved live birth rates in blastocysts with cytoplasmic strings., Comparable outcomes with good quality day 6 and poor quality day 5 embryos, Genetic analysis of arrested embryos reveals 3 distinct types. By assisting with embryo hatching, the process of implantation is started. (2018) found that day 5 embryos performed better than day 6 regardless of grade (29.6% live birth vs 17.0%). 0000006360 00000 n Clinics can have different ways of reporting grades. The blastocyst has a structure called a blastocoel which is the space inside the blastocyst that fills up with water. air quality), Graded as excellent (AA) or good (AB or BA) = 50% live birth, Problems with the vaginal or endometrial microbiota, Anatomical issues (like polyps or fibroids), Immunological issues (autoimmunity, NK cells, T regulatory cells, HLA mismatching), The doctors and embryologists success rates. The blastocyst continues to develop until it reaches the hatching stage. 0000021606 00000 n This was reduced to <10% with <5 cells, or about 10% with >25% fragmentation. The result is a fertilized egg, sometimes called a zygote. How many failed embryo transfers is too many? Hi, . I was so sure it would work first go round for me, since didn't have any history of fertility issues and was young (30). Fully hatched is great! Study design, size, duration: That depends on if they have started the hatching, then the blastocyst will be graded as 4. . Embryos were classified as NFH (expansion Grade 3, 4 or 5) or FH (expansion Grade 6) cohorts. 0000002733 00000 n This information, however, is not intended as medical advice nor is the advice tailored to any specific person or condition and it should not take the place of talking with your doctor or health visitor generally and, specifically, when you are trying to get pregnant. Typically we see around a 95% survival rate. Feb 3, 2011 5:34 PM. But these embryos are considered after high quality embryos, because theyre less likely to work and doctors hope to get you pregnant as fast as possible! This sometimes occurs when cells divide. Your medical team takes a host of other factors into account when they make the decision to transfer: your age, fertility history, which embryos to transfer, how many embryos to transfer and which day will most likely lead to a successful pregnancy. Pirtea et al. Heads up: Blastocyst grading is complex and that means that grades arent carved in stone and may change. This is from my Embryo Gallery where I post pictures of submitted embryo photos and their grades from my supporters. The pregnancy rate per cycle and implantation rate per transferred embryo was 42.1% and 19.4%, respectively, in the blastocyst group compared to 23.6% and 8.6%, respectively, when embryos were transferred on day 2. Do embryo grades matter? So, what are embryologists looking for? Another reason is that embryo grading is subjective, and one embryologist might give it a different grade compared to the original embryologist who graded it. When an embryo breaches the ZP before implanting into the uterus, it is considered to have hatched. Theres a lot of components inside each cell, and this needs to be distributed equally. Curious if that is a good sign or no? Its important to realize that as the embryos expansion number increases above 3, the embryo itself is getting bigger. Poor quality embryos work check your clinics policy on discarding them, Blastocyst embryo grading (Day 5 grading), Variability in expansion embryo grades by clinic or embryologist, ICM and trophectoderm grading for early blastocysts, Embryo compaction may make embryo grading difficult, How blastocyst embryo grades are reported, Day 5 (blastocyst) embryo grades and pictures. I wouldn't worry about it being a 6 day embryo if it is a good quality embryo. 0000057931 00000 n These charts show the options for the number and each letter. Hatching Blastocyst. This study is very interesting! <]>> You want a good amount of snow, and you want it tightly packed, otherwise it will fall apart. Scientific evidence suggests slightly improved chances of clinical pregnancy rates and with increased medical advances, a clearer understanding of the benefits of assisted hatching can be reached. Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, Scepi E, Maggiulli R, Vaiarelli A, Rienzi L, Ubaldi FM. Reaching the end of the fertility trail with a prize to cuddle can be a physically and emotionally draining trek that covers so much uncharted territory. Some embryos arrest because they cant switch from the stored maternal egg factors to the embryos genome, while others have metabolic issues. Expected that to happen further in development in utero and afraid that since it happened early the uterus would have a higher chance of rejecting it - causing implantation to fail. In humans, blastocyst stage of development occurs during the first and second week following fertilization(GAweek 3 and 4) and is described initially as Carnegie stage 3. Expansions of 3 and 4 are also variable. An official website of the United States government. 0000036140 00000 n If you want to check the full summary of this study, I have it on my post Fast growing day 3 embryos and their reproductive potential. The 8 cell is a bit more challenging, because there are cells on top and below the plane of focus (where the microscope is focused). IVF Success Rates with 5 Day Blastocyst Transfers at the Advanced Fertility Center of Chicago. Blastocysts actually expand and contract (or collapse/compact) as a part of their normal development. 0000006660 00000 n These embryos are assisted hatched, where the embryologist uses a laser to make a tiny hole in the zona. The embryos are still at the same size as an unfertilized egg. r. relyn2011. 2022 Sep 26;17(9):e0267652. Assisted hatching. James et al. Why do embryos in IVF fail to implant or miscarry? In conventional IVF, sperm are mixed with the eggs and left to fertilize. 0000028487 00000 n So if theres a low number of cells on day 3, like 4 for example, we might take off points to reflect this. 10/10/2018 15:08. All Rights Reserved, The first parameter refers to the size of the blastocyst and is graded from 1 (smallest), to 5 (largest). Been struggling with my babe only taking contact naps so Ive really been trying to get him to sleep in his bassinet on his own.Today I followed his sleepy cues very carefully and brought his bassinet (that he sleeps in at night) into his nursery My LO will be 3mo on the 21st and weve had a love/hate relationship with swaddles ever since he turned about 3 weeks old.